"Saving" a file is keeping it locally for an undetermined time as it was last saved.
"Preserving" a file is converting a file into an ideal preservation format, verifying its integrity, and storing it in multiple locations with low-access and high-security measures in place to ensure continued access.
See Brian Lavoie's DPC Technology Watch Report on the OAIS reference model for detailed information.
Digital Preservation Coalition
by David S. Rosenthal